(A quantity of 3000μg of Nicomenthyl® was applied to a sample of RHE (in vitro Reconstructed Human Epidermis).

A very high rate of penetration through the stratum corneum was observed, reaching an amount of 53.8% of the applied dose in only 30 minutes.

The whole process of absorption and hydrolysis into its two components, menthol and niacin, gets practically completed in a period of 24 hours after application.

HPLC analysis revealed a total amount of 254μg of released niacin having penetrated through the skin barrier (from the initial 1413μg contained in the 3000μg applied dose of Menthyl nicotinate), i.e. a niacin absorption rate of approx. 18% of the applied dose in 24 hours.

A Doppler Laser Blood-flow Velocity Test has been carried out on twenty volunteers of both sexes, using a topical preparation containing 3% of Nicomenthyl®, compared to a negative control (placebo).

Increases in microcirculatory flow values reached remarkable levels, up to nearly 150% at 30 minutes and 90% at 60 minutes after application, without any irritating or sensitizing effects.

This study was aimed to investigate the protective and antioxidant efficacy of the cosmetic active ingredient of Nicomenthyl®, in a biological experimental model (in vitro culture of human keratinocytes), against two damaging agents: UV radiation and oxidant chemicals.

The efficacy was evaluated both for acute (24 hours) and repeated exposure (72 hours).

CONCLUSIONS:

Nicomenthyl® completely preserves cell viability in human epidermal keratinocytes exposed to UV radiation. Fully protects and significantly increases metabolism of skin cells exposed to oxidant agents.

This study was aimed to investigate the efficacy of Nicomenthyl®, in a biological experimental model (in vitro culture of human keratinocytes), against damages caused by cigarette smoke and urban dust. The efficacy was evaluated both for acute (24 hours) and repeated exposure (72 hours).

CONCLUSIONS:

Nicomenthyl® fully protects and reduces lipoperoxide content in cells exposed to cigarette smoke.

Significantly increases the activity of GST (Glutathione S-transferase, an enzyme which plays a pivotal role in the detoxification and elimination of xenobiotic toxicants) in skin cells exposed to particulate pollutants (urban dust).

A recent in vitro study on cultures of human keratinocytes has shown Nicomenthyl®’s protective and detoxifying efficacy against both, Blue Light and Wi-Fi.

CONCLUSIONS:

Stressed keratinocytes, treated with Nicomenthyl®, showed a significant recovery of GST activity, practically restoring baseline levels, for 24 hours as well as 72 hours exposures, for both damaging agents.