Multichem R&D at In-Cosmetics Global 2025 We are thrilled to announce our participation in In-Cosmetics Global 2025, the leading event for the cosmetic industry, taking place in Amsterdam from April 8 to 10.

Nicomenthyl 20 is a multifunctional sensorial cosmetic active, derived from vitamin B3 (niacin or nicotinic acid), manufactured in Italy by Multichem R&D, through a patented synthesis process.

Nicomenthyl 20 significantly enhances skin microcirculation, without causing hyperemia or irritation. At the contrary, it produces a localized pleasant tingling sensation.

NICOMENTHYL® 20 has shown to have a highly protective, repairing and detox effect not only against damages caused by UV rays, oxidative chemicals, urban particulates and cigarette smoke, but Blue Light and WiFi radiations as well.

Both these types of electromagnetic waves are produced by the common electronic devices, which people are particularly exposed to, sometimes much more intensively than usual, in the lockdown and/or smart working conditions.

NICOMENTHYL® 20 is composed of pure MENTHYL NICOTINATE, with no residues of other nicotinates, obtained through a new and proprietary industrial synthesis process, developed over 20 years of research by Dr. Gabriele Segalla at Multichem R&D Laboratories, in Milan, Italy. NICOMENTHYL 20 represents a new and revolutionary substance for cosmetic use that can significantly activate the cutaneous microcirculation without causing bothersome hyperemia or irritations, on the contrary it generates a pleasant hot-cold sensation in the area of application.

Skin Penetration Study Protocol: this test method has been designed to provide information on absorption of a test substance applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell. In vivo viable human skin has been used.

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation and xenobiotics.